Goals from Fernando Torres and Victor Moses in the first leg allow Rafa Benitez's men a bit of breathing space as they make the long trip to the Russian capital.
By Al Hain-Cole, Goal.com editor.
Kaleshin, Navas, Sharonov, Ansaldi
Kasaev, Eremenko, Karadeniz
Azpilicueta, Ivanovic, Terry, Bertrand
Moses, Oscar, Hazard
Vladimir Dyadyun will compete for a place up front with Salomon Rondon for the hosts, who have no injury concerns to speak of.
Cesar Navas, Ivan Marcano and Roman Sharonov will fight for two places in the centre of defence, while Oleg Kuzmin may replace Gokdeniz Karadeniz on the right-hand side of midfield.
Chelsea face a potential dilemma at left-back, where Ashley Cole's (hamstring) usual deputy Ryan Bertrand is struggling with a virus. Nathan Ake is the club's only other natural left-back, while Paulo Ferreira could fill in from his preferred right-back position.
Gary Cahill is still a couple of weeks away from returning after undergoing minor arthroscopic surgery to shave the meniscus on the knee he damaged in last month's win against West Ham.
With Demba Ba cup-tied, Fernando Torres will continue up front, having scored twice in the first leg at Stamford Bridge.
David Luiz, Ramires and Juan Mata are likely to be rested after playing three games in less than a week, so John Terry, Frank Lampard and Victor Moses should come into the starting line-up.